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Biology Program

Dr. Eduardo Martinez-Ceballos

Eduardo Martinez-Ceballos, Ph.D.,

 

Martinez picture for Website.jpg

 

Eduardo Martinez-Ceballos, Ph.D. Professor and Chair, Department of Biological Sciences and Chemistry

Office: 217 Health Research Center
Laboratory: 216 Health Research center. Lab Website

Phone: (225) 771-3606

Fax: (225) 771-3606

E-mail: eduardo_martinez@subr.edu

 

Biography

Dr. Martinez-Ceballos is a Professor in the Department of Biological Sciences and Chemistry. He received his Ph.D. in Cell and Molecular Biology in 2001 from Tulane University, New Orleans. He then worked as a Postdoctoral Researcher in the laboratory of Dr. Lorraine Gudas at the Weill Cornell Medical College in New York City. Dr. Martinez-Ceballos became an Assistant Professor at Southern University in August 2007. In 2012 he became a tenured Associate Professor and was promoted to Full Professor in 2017. The main project in Dr. Martinez-Ceballos laboratory focuses on the role of the Hoxa1 transcription factor on the differentiation of mouse embryonic stem cells (ESCs) along a neuroectodermal pathway. The long-term goal of this project is to elucidate and characterize the molecular mechanisms by which the Hoxa1 transcription factor directs the differentiation of embryonic stem cells into neurons. This project is currently funded by an AREA grant (R15) from the NIH.

Dr. Martinez-Ceballos has trained a number of both undergraduate and graduate students in the areas of Stem Cell and Cancer research since 2007. Four Ph.D., three Masters, and five undergraduate students have completed their thesis dissertations working under his direction. Currently, six students (graduate and undergraduate) work on different projects in his laboratory.

Areas of Interest

  • Role of Homeobox Transcription Factors on the neuronal differentiation of mouse Embryonic Stem (ES) cells.
  • Effect of environmental pollutants on neurite outgrowth of in vitro-generated GABAergic versus glutamatergic neurons.
  • Mechanism of Cancer Stem Cell (CSC) induction by environmental pollutant exposure of human cancer cell lines.

Awards & Honors

2010    Outstanding Research Award, Honors College, SUBR

2011    Faculty Researcher of the Year. College of Sciences, SUBR, Louisiana

2014    Rising Star Researcher, Southern University System, Louisiana.

Teaching  (since 2007)

  • Cell and Molecular Biology (BIOL 402, undergraduate)
  • Molecular and Celular Biology (BIOL 550, Master's program)
  • Advanced Biochemistry (ENTX 732, Ph.D. program)

Selected Publications 

Kona, S.L., Shrestha, A., Yi, X., Joseph, S., Barona, H.M., Martinez-Ceballos E. (2017). RARβ2-dependent signaling represses neuronal differentiation in mouse ES cells. Differentiation. Nov 10;98:55-61. doi: 10.1016/j.diff.2017.11.002. [Epub ahead of print]

Al-Bagdadi F, Young MJ, Geaghan JP, Yao S, Barona HM, Martinez-Ceballos E, Yoshimura M. (2016). Observation on the ultrastructure morphology of HeLa cells treated with ethanol: Statistical analysis. Ultrastruct Pathol. 40(6), 324-332. Epub 2016 Sep 28.PMID:27680498.

C. Addae, H. Cheng, and E. Martinez-Ceballos (2013). Effect of the environmental pollutant hexachlorobenzene (HCB) on the neuronal differentiation of mouse embryonic stem cells. Int. J, Environ. Res. Publ. Health 10, 5244-5256.

C. Addae, X. Yi, R. Gernapudi, H. Cheng, A. Musto, and E. Martinez-Ceballos (2012). All-trans-retinoid acid induces the differentiation of encapsulated mouse embryonic stem cells into GABAergic neurons., Differentiation 83, 233-241.

W. Allen, H. Munoz-Barona, and E. Martinez-Ceballos (2011). Optimization of electroporation conditions for DU145 human prostate cancer cells using multiobjective programming. Louisiana Scientist: The Newsletter of the LAS, 2,  18-19.

E. Martinez-Ceballos and L.J. Gudas (2008). Hoxa1 is required for the retinoic acid-induced differentiation of embryonic stem cells into neurons.. J. Neurosci. Res. 86, 2809-2819.

S. Yadavilli, E. Martinez-Ceballos, J. Snowden-Aikens, A. Hurst, T. Darby, T. Joseph, T. Albrecht, and P.M. Muganda (2007). Diepoxybutane activates the mitochondrial apoptotic pathway and mediates apoptosis in human lymphoblasts through oxidative stress. Toxicol. In Vitro. 21, 1429-1441.

E. Martinez-Ceballos, P. Chambon, and L.J. Gudas (2005). Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal.. J. Biol. Chem. 280, 16484-16498.

E. Martinez-Ceballos and C.A. Burdsal (2001).  J.

Differential expression of chicken CYP26 in anterior versus posterior limb bud in response to retinoic acid. Exp. Zool. 290, 136-147.

(find out more at the Martinez Lab Page.