Southern University and Agricultural and Mechanical College

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Curriculum Vitae

Uppu's Laboratory

Postdoctoral Fellows

Current Students

Former Students


Rao M Uppu, Ph.D., DABT,  ATS

Professor and Director, Environmental PhD Program

Director, Health Research Center

Phone: (225) 771-4303

Fax: (225) 771-5350


Office: 108 Fisher Hall (ENTX)

             128 Lee Hall (HRC)


Dr. Rao Uppu is a professor of environmental toxicology at Southern University-Baton Rouge (SUBR), with adjunct appointments in the Department of Chemistry and the Graduate School. He is also an adjunct professor of pathobiological sciences at the LSU School of Veterinary Medicine. Dr. Uppu obtained his PhD degree in biochemistry in 1988 and carried out his postdoctoral research in several NIH-funded projects in the areas of chemical carcinogenesis and oxidative chemistry/biology at the Eppley Institute for Research in Cancer and Allied Diseases (Omaha, NE) and the Biodynamics Institute at LSU (Baton Rouge, LA). After a brief stay at the US Patent & Trademark Office (2001-2002), then located in Arlington, VA, Dr. Uppu joined SUBR in 2002 as a tenure-track associate professor and rose to the ranks of a full professor with tenure in 2007. Dr. Uppu has mentored numerous graduate students (MS and PhD) and postdoctoral fellows and has published over 65 articles in peer-reviewed journals and book series. He is an elected Fellow of the Academy of Toxicological Sciences, and was honored with numerous awards for teaching and research. Currently, Dr. Uppu directs the Environmental Toxicology PhD program and also the Health Research center at SUBR.

Area of Interest

Dr. Uppu's research interests include analytical methods for biological reactive intermediates, biomarker discovery and validation, cell signaling by 'ozone-specific' oxysterols, and biomedical applications of core/shell nanoparticles.

Awards & Honors

2006       Outstanding Reseacher (Natural Sciences), College of Sciences, SUBR

2006       Associate Editor, Journal of Alzheimer's Disease (JAD), IOM Press.

2007       Faculty Researcher of the Year (Natural Sciences), College of Sciences, SUBR.

2007       Co-Editor-in-Chief, SMART Findings: An Undergraduate STEM Research Journal

2007       Outstanding Research Investigator (University-wide), SUBR.          

2009       Distinquihed Researcher, Louisian Biomedical Reseach/National Institutes of Health

2010       Lead Editor, Free Radical and Antioxidant Protocols. Second Edition (ISBN: 978-1-58829- 710-5; R.M. Uppu, S.N. Murthy, W.A. Pryor, and N.L. Parinandi - Eds.), Methods Mol Biol, Vol. 610, Humana (Springer) Press, Totowa, NY

2011       Southern University Business and Industry Cluster (BIC) Quality Award. 

2011       Telugu Association of North America (TANA) Excellence in Science Award

2012­-14 Editor-in-Chief, Journal of Diabetes & Metabolism (JDM), OMICS Publications

2013       SUBR Millionaire Club

2013       Chacellor's Award for Excellence in Teaching, SUBR.

2013-      Member, Southern University Intellectual Property Committee (IPC)

2013-      Fellow of the Academy of Toxicological Sciences (ATS)

Teaching  (doctoral level; since 2002)

ENTX 725 Biochemical & Molecular Toxicology (fall); ENTX 736 Special Topics (spring); ENTX 737 Biochemical Methods (fall, spring, and summer); ENTX 799 Research Practicum (fall, spring, summer); ENTX 800 Dissertation Research  (fall, spring, and summer)  

Selected Publications (in reverse chronological order; from over 65)

F. Mohammad, A.C. Raghavamenon, M.O. Claville, C.S. Kumar, and R.M. Uppu (2014). Targeted hyperthermia-induced cancer cell death by gold-coated superparamagnetic iron oxide nanoparticles (SPIONs@Au) conjugated luteinizing hormone-releasing hormone (LHRH). Nanotechnol. Rev. March 2014. DOI: 10.1515/ntrev-2013-0041.

S. Babu, V. Nadeem, A.V. Kasibotla, H.J. Dwayne, M.A. Stubblefield, and R.M. Uppu (2012). Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma.  Biochem. Biophys. Res. Commun.  426, 215-220; doi: 10.1016/j.bbrc.2012.08.065.

F. Mohammad, G. Balaji, A. Weber, R.M. Uppu, and C.S. Kumar (2010). Influence of gold nanoshell on hyperthermia of super paramagnetic iron oxide nanoparticles (SPIONs). J. Phys. Chem. C  114, 19194-19201.

K. Sathishkumar, X. Gao, A.C. Ragavamenon, N.L. Parinandi, W.A. Pryor, and R.M. Uppu (2009).  Cholesterol secoaldehyde induces apoptosis in cardiomyocytes through reactive oxygen species involving mitochondrial and death receptor pathways. Free Radic. Biol. Med. 47, 548-558.

K. Sathishkumar, X. Xi, R.J. Martin, and R.M. Uppu (2007). Cholesterol secoaldehyde induces amylodogenesis and apoptosis in murine GT1-7 hypothalamic neuronal cells. J. Alzheimer's. Dis. 11, 261-274.

C.-J. Dupard, B. Kandlakunta, and R.M. Uppu (2007). A reversed phase HPLC method for the determination of epoxides of 1,3-butadiene and other petrochemical alkenes. Anal. Bioanal. Chem. 387, 1027-1032.

R.M. Uppu (2006). Synthesis of peroxynitrite using isoamyl nitrite and hydrogen peroxide in a homogeneous solvent system. Anal. Biochem. 354, 165-168.

R. Cong, E. Tamyanko, P.S. Russo, N. Edwin, and R.M. Uppu (2006). Dynamics of poly(styrene-sulfonate) in sodium salt in aqueous solution. Macromolecules 39, 731-739.

K. Sathishkumar, M. Haque, T.E. Perumal, J. Francis, and R.M. Uppu (2005). A major ozonation product of cholesterol, 3b-hydroxy-5-oxo-5,6-secocholestan-6-al, induces apoptosis in H9c2cardiomyoblasts.  FEBS Lett. 579, 6444-6450.

R.M. Uppu, G.L. Squadrito, R.M. Bolzan, and W.A. Pryor (2000). Nitration and nitrosation by peroxynitrite: Role of CO2 and evidence for common intermediates. J. Am. Chem. Soc. 122, 6911-6916.

R.M. Uppu and W.A. Pryor (1999). Nitrosation of 1,2-phenylenediamine by peroxynitrite/CO2. Evidence for a free radical mechanism. J. Am. Chem. Soc. 121, 9738-9739.

R.M. Uppu, G.W. Winston, and W.A. Pryor (1997). Reactions of peroxynitrite with aldehydes as probes for the reactive intermediates responsible for biological nitration. Chem. Res. Toxicol. 10, 1331-1337.

R.M. Uppu and  W.A. Pryor (1996). Carbon dioxide catalysis of the reaction of peroxynitrite with ethyl acetoacetate. An example of aliphatic nitration by peroxynitrite. Biochem. Biophys. Res. Commun. 229, 764-769.

R.M. Uppu, R. Cueto, G.L. Squadrito, M.G. Salgo, and W.A. Pryor (1996). Competitive reactions of   peroxynitrite with 2'-deoxyguanosine and 7,8-dihydro-8-hydroxy-2'-deoxyguanosine (8-oxodG): Relevance to the formation of 8-oxodG in DNA exposed to peroxynitrite. Free Radic. Biol. Med. 21, 407-411.

R.M. Uppu, R. Cueto, G.L. Squadrito, and W.A. Pryor (1995). What does ozone react with at the air lung interface-model studies using human red-blood cell membranes.Arch.  Biochem. Biophys. 319, 257-266.

R.M. Uppu (1995). Novel kinetics in a biomimetic redox reaction involving NADH and tetrazolium salts in aqueous micellar solutions. J. Inorg. Biochem. 58, 193-207.

R.M. Uppu (1995). Phenazine/dihydrophenazine redox couple as an inoffensive catalytic probe discerns premicellar aggregation in dilute aqueous solutions of Triton X-100. Langmuir 11, 1038-1040.

W.A. Pryor, R. Cueto, X. Jin, W.H. Koppenol, M. Ngu-Schwemlein, G.L. Suadrito, P.L. Uppu, and R.M. Uppu (1995). A practical method for preparing peroxynitrite solutions of low ionic strength and free of hydrogen peroxide. Free Radic. Biol. Med. 18, 75-83.

W.A. Pryor and R.M. Uppu (1993). A kinetic model for the competitive reactions of ozone with amino acid residues in proteins in reverse micelles. J. Biol. Chem. 268, 3120-3126.

R.M. Uppu and W.A. Pryor (1994). The reactions of ozone with proteins and unsaturated fatty acids in reverse micelles. Chem. Res. Toxicol. 7, 47-55.


For additional publication list and other information, please refer to the following sites