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Eduardo Martinez-Ceballos, Ph.D.

Associate Professor

Biological Sciences and Environmental Toxicology PhD Program

Phone: (225) 771-3606

Fax: (225) 771-3606

E-mail: eduardo_martinez@subr.edu

Office: 216 HRC


Biography

Dr. Martinez-Ceballos is an Associate Professor in the Department of Biology, Chemistry, and Environmental Toxicology. He received his Ph.D. in Cell and Molecular Biology in 2001 from Tulane University, New Orleans. He then worked as a Postdoctoral Researcher in the laboratory of Dr. Lorraine Gudas at the Weill Cornell Medical College in New York City. Dr. Martinez-Ceballos became an Assistant Professor at Southern University in August 2007 and in 2012 he became a tenured Associate Professor. The main project in Dr. Martinez-Ceballos laboratory focuses on the role of the Hoxa1 transcription factor on the differentiation of mouse embryonic stem cells (ESCs) along a neuroectodermal pathway. The long-term goal of this project is to elucidate and characterize the molecular mechanisms by which the Hoxa1 transcription factor directs the differentiation of embryonic stem cells into neurons. This project is currently funded by an IDeA Networks of Biomedical Research Excellence (LSU/INBRE) grant from the NIH.

Dr. Martinez-Ceballos has trained a number of both undergraduate and graduate students in the areas of Stem Cell and Cancer research since 2007. Four Ph.D., three Masters, and five undergraduate students have completed their thesis dissertations working under his direction. Currently, six students (graduate and undergraduate) work on different projects in his laboratory.


Areas of Interest

  • Role of Homeobox Transcription Factors on the neuronal differentiation of mouse Embryonic Stem (ES) cells.
  • Effect of environmental pollutants on neurite outgrowth of in vitro-generated GABAergic versus glutamatergic neurons.
  • Mechanism of Cancer Stem Cell (CSC) induction by environmental pollutant exposure of human cancer cell lines.

Awards & Honors

2010    Outstanding Research Award, Honors College, SUBR

2011    Faculty Researcher of the Year. College of Sciences, SUBR, Louisiana

2014    Rising Star Researcher, Southern University System, Louisiana.


Teaching  (doctoral level; since 2007)

ENTX 723 Advanced Biochemistry; ENTX 736 Special Topics; ENTX 800 Dissertation Research      


Selected Publications 

C. Addae, H. Cheng, and E. Martinez-Ceballos (2013). Effect of the environmental pollutant hexachlorobenzene (HCB) on the neuronal differentiation of mouse embryonic stem cells. Int. J, Environ. Res. Publ. Health 10, 5244-5256.

C. Addae, X. Yi, R. Gernapudi, H. Cheng, A. Musto, and E. Martinez-Ceballos (2012). All-trans-retinoid acid induces the differentiation of encapsulated mouse embryonic stem cells into GABAergic neurons, Differentiation 83, 233-241.

W. Allen, H. Munoz-Barona, and E. Martinez-Ceballos (2011). Optimization of electroporation conditions for DU145 human prostate cancer cells using multiobjective programming. Louisiana Scientist: The Newsletter of the LAS, 2,  18-19.

E. Martinez-Ceballos and L.J. Gudas (2008). Role of Hoxa1 during the neuronal differentiation of embryonic stem cells in vitro. J. Neurosci. Res. 86, 2809-2819.

S. Yadavilli, E. Martinez-Ceballos, J. Snowden-Aikens, A. Hurst, T. Darby, T. Joseph, T. Albrecht, and P.M. Muganda (2007). Diepoxybutane activates the mitochondrial apoptotic pathway and mediates apoptosis in human lymphoblasts through oxidative stress. Toxicol. In Vitro. 21, 1429-1441.

E. Martinez-Ceballos, P. Chambon, and L.J. Gudas (2005). Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or LIF removal. J. Biol. Chem. 280, 16484-16498.

E. Martinez-Ceballos and C.A. Burdsal (2001). Differential Expression of Chicken CYP26 in Anterior versus Posterior Limb Bud in Response to Retinoic Acid. J. Exp. Zool. 290, 136-147.

 

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